药物科学与工程系

研究领域：肥胖与代谢疾病调控机制研究及相关食药产品开发
研究团队针对肥胖及相关代谢疾病（二型糖尿病、脂肪肝等）的发生和防治，基于“免疫-代谢”调控理论，利用小鼠、线虫和大肠杆菌等模式生物，研究细胞代谢调控相关的生物学、营养学和药理学机制，发展相关食材和中药材的加工技术，研发抗肥胖及上述相关代谢疾病的食品、药品。具体研究方向包括：
1、肥胖等代谢疾病“免疫-代谢”调控和营养干预机制研究；
2、抗肥胖等代谢疾病功能食品加工过程营养与安全学研究；
3、抗肥胖等代谢疾病药食同源中药材物质基础、活性功能和药理机制研究；
4、功能食品和中药材相关生物质资源综合利用研究。

近10年来，主持国家自然科学基金面上项目等纵横向项目10余项，团队总到账经费逾1000万元。

发表高质量论文40余篇，本人作为通讯或第一作者的10篇代表性论文包括：
1) Lin Y, Bao B*, Yin H, Wang X, Feng A, Zhao L, Nie X, Yang N, Shi GP, Liu J*. Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis. BMC Biology. 2019;17(1):93. (IF=6.765)

2) Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP*, Liu J*. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Reports. 2019;28(3):792-803.e4. (IF=8.109)

3) Bi Y, Ye L, Mao Y, Wang L*, Qu H*, Liu J*, Zheng L*. Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for ultrasensitive and real-time detection of lactic acid from cancer cell metabolism. Biosensors & Bioelectronics. 2019; 140:111-119. (IF=10.257)

4) Zhang X, Huang Q, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J*, Shi G-P*. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2019; 1865(6):1690-1700. (IF=4.352)

5) Zhang X, Zhang QX, Wang X, Zhang L, Qu W, Bao B, Liu CA, Liu J*. Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism. International Journal of Obesity. 2016; 40(12):1841-1849. (IF=4.419) (Times Cited:34)

6) Zhang L, Han YJ, Zhang X, Wang X, Bao B, Qu W, Liu J*. Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages. Diabetologia. 2016; 59(10):2219-2228. (IF=7.518) (Time Cited:16)

7) Xu N, Zhang L, Dong J, Zhang X, Chen YG, Bao B, Liu J*. Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Molecular Nutrition & Food Research. 2014; 589(6): 1258-1268. (IF=5.309) (Times Cited: 46).

8) Dong J, Zhang X, Zhang L, Bian HX, Xu N, Bao B, Liu J*. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPK α1/SIRT1. Journal of Lipid Research. 2014, 55(3):363-374. (IF=4.483) (Times Cited: 128)

9) Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Doria A, Libby P, Blumberg RS, Kahn BB, Shi GP*. Genetic Deficiency and pharmacological stabilization of mast cells reduces diet-induced obesity and diabetes in mice. Nature Medicine. 2009; 15(8):940-947. (IF=36.13) (Times Cited: 467)

10) Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP*. Lysosomal cysteine proteases in atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 24(8):1359-1366. (IF=6.604) (Times Cited: 307)

1.437ccm必赢国际研究员
2.“黄山学者”特聘教授、校学术委员会委员
3.安徽省欧美同学会常务理事
4.合肥工业大学留学归国人员联谊会副会长
5.中国生物物理学会脂质代谢与生物能学分会理事、中国生物化学与分子生物学会脂质与脂蛋白委员会委员、安徽省生物化学与分子生物学会副理事长、安徽省细胞生物学会常务理事、安徽省色谱分析学会常务理事
6.高质量学术期刊Journal of Nutritional Biochemistry（IF=4.873）、Food Science and human wellness（IF=2.455）编委。